Visual Outcomes Following Surgical Treatment of Pituitary Adenomas: Functional Versus Non-Functional
by Pichaya Kulniwatcharoen, Chanakarn Piamjitchol, Pavinee Tangkitchot, Tanat Vaniyapong, Kittisak Unsrisong and Linda Hansapinyo
Journal
Biomedical Sciences and Clinical Medicine
Volume
63
Issue
4 (October – December 2024)
Publisher
Chiang Mai University
ISSN
2774-1079
Abstract
OBJECTIVE This study aims to compare visual outcomes following sur-gical resection of functional and non-functional pituitary adenoma.METHODS A retrospective observational study included 103 patients with pituitary adenoma who underwent tumor resection at Chiang Mai university hospital between January 2010 and December 2019. Basic charac-teristics, tumor specific data, hormonal status and neuro-ophthalmic data were collected and statistically analyzed to identify differences in visual outcomes between functional and non-functional tumors.RESULTS Between the 51 (49.50%) functional pituitary adenoma and 52 (50.50%) non-functional pituitary adenoma patients in this study, there were no differences in mean age at initial visit, sex, duration of onset, type of surgery, or adjunct radiotherapy. Initial visual acuity in logMAR in both the better and the worse eye, as well as the initial visual impairment score (VIS) which represents a combination of visual acuity and visual field, showed no statistically significant differences. The final visual acuity of the better eye was significantly better in the functional group (0.08± 0.15) than in the non-functional group (0.22±0.47), with a p-value of 0.04. Similarly, the VIS score was significantly better in the functional group (18.37±19.85) than in the non-functional group (28.87±26.83), with a p-value of 0.028. CONCLUSIONS Patients with functional pituitary adenomas have poten-tially better visual outcomes than those with non-functional pituitary adenomas after surgical resection.